Age-associated memory impairment and related disorders
نویسندگان
چکیده
منابع مشابه
KCNQ Channels Regulate Age-Related Memory Impairment
In humans KCNQ2/3 heteromeric channels form an M-current that acts as a brake on neuronal excitability, with mutations causing a form of epilepsy. The M-current has been shown to be a key regulator of neuronal plasticity underlying associative memory and ethanol response in mammals. Previous work has shown that many of the molecules and plasticity mechanisms underlying changes in alcohol behavi...
متن کاملFactors Associated With Age-related Hearing Impairment
Age-related hearing impairment (ARHI) is a complex degenerative disease in the elderly. As multiple factors interact during the development of ARHI, it is important to elucidate the major influencing factors to understand and prevent ARHI. We aimed to identify risk factors associated with the development of ARHI with a retrospective cohort from 2001 to 2010. The records of the adult subjects ov...
متن کاملAlzheimer’s Disease, Amnestic Mild Cognitive Impairment, and Age-Associated Memory
Alzheimer’s disease (AD) is the most common form of dementia. AD initially targets memory and progressively destroys the mind. The brain atrophies as the neocortex suffers neuronal, synaptic, and dendritic losses, and the “hallmark” amyloid plaques and neurofibrillary tangles proliferate. Pharmacological management, at best, is palliative and transiently effective, with marked adverse effects. ...
متن کاملGenetic Dissection of Age-related Memory Impairment in Drosophila
Age-related memory impairment (AMI) is an important phenotype of brain aging. Understanding the molecular mechanisms underlying AMI is important not only from a scientific viewpoint but also for the development of therapeutics that may eventually lead to developing drugs to combat memory loss. AMI has been generally considered to be an overall or nonspecifi c decay of memory processes that resu...
متن کاملAge-related memory impairment associated with loss of parietal deactivation but preserved hippocampal activation.
The neural underpinnings of age-related memory impairment remain to be fully elucidated. Using a subsequent memory face-name functional MRI (fMRI) paradigm, young and old adults showed a similar magnitude and extent of hippocampal activation during successful associative encoding. Young adults demonstrated greater deactivation (task-induced decrease in BOLD signal) in medial parietal regions du...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Advances in Psychiatric Treatment
سال: 1999
ISSN: 1355-5146,1472-1481
DOI: 10.1192/apt.5.4.279